http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018519249-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2018519249-A |
| titleOfInvention | Isoxazolyl-substituted benzimidazoles |
| abstract | Formula (I): (wherein R0 and R are the same or different and are each H or C1-6 alkyl; R9, R9 ′ and R9 ″ are the same or different and are each H Or F; X is-(alk) n-, -alk-C (= O) -NR-, -alk-NR-C (= O)-or -alk-C (= O)- R1 is selected from -S (= O) 2R '; an unsubstituted or substituted 4-6 membered C-linked heterocyclic group; and an N-linked spiro group of the formula: R2 and R2' are Are the same or different and are each H or C1-6 alkyl, or R2 and R2 'together with the C atom to which they are attached form a C3-6 cycloalkyl group R3 and R3 ′ are the same or different and are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered, N-containing heteroaryl group, unsubstituted Or alk is C1-6 alkylene; R ′ is C1-6 alkyl; and n is 0 or Is benzimidazolyl isoxazole, or a pharmaceutically acceptable salt thereof. The compounds have the activity of modulating the activity of p300 and / or CBP and are used to treat cancer, particularly prostate cancer. [Selection figure] None |
| priorityDate | 2015-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 472.