http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018518149-A
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2878 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 |
filingDate | 2016-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2018-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2018518149-A |
titleOfInvention | Glycoprotein modification method using glycosyltransferase that is or is derived from β (1,4) -N-acetylgalactosaminyltransferase |
abstract | The present invention relates to a method for enzymatic modification of glycoproteins. This method involves converting a glycoprotein comprising a glycan containing a terminal GlcNAc moiety into a non-natural sugar derivative in the presence of a glycosyltransferase that is or is derived from β- (1,4) -N-acetylgalactosaminyltransferase. Contacting with a nucleotide. The non-natural sugar derivative nucleotide has the formula (3): (In the formula, A represents —N 3 , —C (O) R 3 , —C (H 2 ) i C≡C—R 4 , —SH, —SC (O) R 8 , —SC (O) OR 8. , -SC (S) OR 8, -F, -Cl, -Br, -I, -OS (O) 2 R 5, terminal C 2 -C 24 alkenyl group, C 3 -C 5 cycloalkenyl group, C 4 -C 8 alkadienyl group, represented by terminal C 3 -C selected from the group consisting of 24 allenyl group and an amino group). The present invention relates to a glycoprotein obtained by the method of the present invention, a bioconjugate obtainable by conjugating a glycoprotein and a linker-conjugate, and β usable in preparing the glycoprotein of the present invention. Further relates to-(1,4) -N-acetylgalactosaminyltransferase. [Selection figure] None |
priorityDate | 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 681.