| abstract |
The present invention relates to inhibitors of PPP1R15A and PPP1R15B and their use in therapy, in particular in the treatment of pathologies that are alleviated by inhibition of PPP1R15A and PPP1R15B, such as disorders associated with misfolded protein accumulation or proteostasis disorders. About. The compounds of the present invention include a compound having the formula IA, wherein R1a, R3a, R5a, Xa and Ya are defined herein, or a pharmaceutically acceptable salt thereof. [Selection figure] None |