| abstract |
The present invention relates to human papillomaviruses that can be used to selectively target the HPV genome or to selectively express a nuclease capable of targeting the target in cells infected with HPV ( Compositions and methods for treating HPV) infections using nucleases capable of targeting the target are provided. By selectively targeting cells infected with HPV, the HPV genome in infected cells, or both, the nuclease can cleave the HPV genome, thereby inactivating and rendering it inoperable. Hinders the ability of the virus to propagate, even when the virus is a latent stage of infection. Because the latent HPV can be cleaved and eradicated from the host cell, the compositions and methods of the present invention strongly prevent many adverse health events associated with papillomavirus to treat HPV infection. Can be used for. |