| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2250-0067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-258
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-2412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3625
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-2418
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-397 |
| filingDate |
2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2018-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2018516624-A |
| titleOfInvention |
Devices and methods for inhibiting stenosis, occlusion or calcification of natural heart valves, stented heart valves or bioprostheses |
| abstract |
The present invention relates to stenosis, occlusion or calcification of a valve of a natural valve that develops a disease via the Lrp5 / Wnt pathway after implantation of a valve prosthesis or in the presence of elevated lipid due to elevated low density lipoprotein. The present invention relates to a method for suppressing crystallization. The present invention involves administering a combination of medications to target inflammation and target cell attachment, and a second drug to inhibit proliferation and calcification on elastic stents, gortex grafts or valvular membranes. . Combination therapy suppresses bioprosthesis and natural valve calcification with improved life of artificial materials including stents, natural valves and gortex covers. The valve prosthesis and / or gortex implant is mounted on an elastic stent or prosthesis such that the elastic stent is connected to the valve. |
| priorityDate |
2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |