| abstract |
The present invention relates to retroviral systems for the transfer of non-viral RNA to target cells, and more specifically to retroviral particles capable of delivering multiple RNAs. More specifically, the present invention is a retroviral particle comprising a protein derived from a Gag polyprotein, an envelope protein, optionally an integrase and at least two encapsidated non-viral RNA, Each non-viral RNA comprises an RNA sequence of interest linked to an encapsidation sequence, each encapsidation sequence being recognized by a binding domain introduced into a protein derived from a Gag polyprotein and / or into an integrase. Is related to retroviral particles. |