| abstract |
The present invention relates to a humanized antibody specific to antigen CD3 or a fragment thereof, comprising a heavy chain variable domain comprising the CDR1 region of SEQ ID NO: 1, the CDR2 region of SEQ ID NO: 2 and the CDR3 region of SEQ ID NO: 3, An antibody, or fragment thereof, comprising a light chain variable domain comprising four CDR1 regions, a CDR2 region of SEQ ID NO: 5 and a CDR3 region of SEQ ID NO: 6. Furthermore, the present invention is a method for polyclonal stimulation of T cells comprising contacting a T cell population with said anti-CD3 antibody, optionally anti-CD28 antibody, wherein said anti-CD3 antibody and optionally said anti-CD28 antibody are particles To provide a method. Furthermore, the anti-CD3 antibody can be used for reversible tagging of cells. |