| abstract |
The following formula (I): Wherein R 1 is methyl, ethyl, halo, or heteroaryl optionally substituted by ═O, and R 2 is H, methyl, or ethyl, and salts thereof, KMO inhibitor, various disorders such as acute pancreatitis, chronic kidney disease, other symptoms related to systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxia, Parkinson's disease, AIDS dementia complication , HIV infection, amyotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe It may be useful for the treatment of burns, pneumonia, extensive surgery, ischemic bowel disease, severe acute liver disease, severe acute hepatic encephalopathy, or acute renal failure. |