| abstract |
The present invention provides a recombinant bifunctional fusion protein. The fusion protein comprises an Ig-like domain (SIRPαD1) at the outer membrane end of human signal regulatory protein alpha (SIRPα) and an Fc fragment of human IgG1. Further provided are a polynucleotide encoding the fusion protein, an expression carrier comprising the polynucleotide, a method for preparing the fusion protein, and a method for treating a disease that overexpresses CD47. |