| abstract |
The present application relates to an immunogenic composition comprising a mixture of a Volteterra (eg B. pertussis) antigen and an oil-in-water nanoemulsion. In particular, the present invention relates to nanoemulsions and combinations of multiple Borteterra (eg, B. pertussis) antigens having different functions (eg, B. pertussis adhesion factor (adhesin), B. pertussis toxin, or B. pertussis virulence factors and the like) is provided. Also described are vaccines, methods of treatment, use of pertussis or whooping cough vaccines, and methods for producing pertussis vaccines. The crude and methods of the present invention have been found to be useful for clinical applications (eg, therapeutic and prophylactic (eg, vaccination)) and research applications, among others. |