| abstract |
The present disclosure inhibits the activity of TGFβ superfamily ligands, particularly ligands such as GDF8, GDF11, Activin A, Activin B, Activin C and Activin E, in vertebrates, including rodents and primates, particularly humans. Compositions and methods are provided. The compositions of the present disclosure contain a protein complex / fusion comprising a heteromeric Fc interaction pair in which follistatin-related polypeptides are associated covalently or non-covalently. The composition can be used for the treatment or prevention of diseases or disorders associated with abnormal activity of follistatin related polypeptides and / or follistatin ligands. |