| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-025
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8778
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-873 |
| filingDate |
2016-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2018506984-A |
| titleOfInvention |
ETV2 and its use |
| abstract |
Described herein is a method for producing a chimeric non-human animal that expresses the human ETV2 gene, comprising the following steps: (a) generating an ETV2 null non-human animal cell in which both copies of the non-human ETV2 gene have a mutation that interferes with the production of functional ETV2 protein in the non-human animal; (b) Fusing the nucleus derived from the ETV2 null non-human animal cell of (a) to an enucleated non-human oocyte, and activating the oocyte to produce an ETV2 null non-human blastocyst Creating an ETV2 null non-human blastocyst by somatic cell nuclear transfer, including dividing to form; (c) introducing human stem cells into the ETV2 null non-human blastocyst of (b); and (d) Transplanting the blastocyst of (c) into a surrogate mother non-human animal during pseudopregnancy to produce a chimeric non-human animal expressing human ETV2. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11673928-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10897880-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10874092-B2 |
| priorityDate |
2015-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |