| abstract |
The present disclosure provides a binding-inducible transcription switch polypeptide, a nucleic acid comprising a nucleotide sequence encoding the binding-inducible transcription switch polypeptide, and a host cell genetically modified with the nucleic acid. The disclosure also provides a chimeric Notch receptor polypeptide, a nucleic acid comprising a nucleotide sequence encoding the chimeric Notch receptor polypeptide, and a host cell transduced and / or genetically modified with the nucleic acid. The present disclosure provides a transgenic organism comprising a nucleic acid encoding the binding-inducible transcription switch polypeptide and / or chimeric Notch receptor polypeptide of the present disclosure. The binding-induced transcription switch polypeptides and chimeric Notch receptor polypeptides of the present disclosure are useful in a variety of applications that are also provided. [Selection figure] None |