abstract |
This invention relates to a mild and highly efficient initial synthesis of primary amines and amides from aldehydes or ketones using heterogeneous metal catalysts and amine donors. The heterogeneous metal catalyzed initial reaction between the carbonyl and amine donor components is followed by the addition of the appropriate acylating agent component in one pot. Accordingly, the present invention provides a novel catalytic one-pot three-component synthesis of amides. Furthermore, the incorporation of enzyme catalyzed reactions allows for the environmentally friendly one-pot cocatalytic synthesis of amides from aldehyde and ketone substrates, respectively. This treatment can be applied to the cocatalytic one-pot three-component synthesis of capsaicin and its analogs from vanillin or vanillyl alcohol. This can also be applied to asymmetric synthesis. In the present invention, a novel cocatalytic reductive amination / dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. In addition, the implementation of the catalytic reductive amination / kinetic resolution (kr) relay sequence can be performed with the corresponding optically active amide product and optically active primary amine having the opposite stereochemistry to the starting ketone. A product is produced. |