abstract |
Described herein are methods, compositions and kits comprising anti-RING antibody branches useful for detecting and / or treating CNS demyelinating diseases. The present invention at least partially provides methods and compositions for treating or preventing CNS disorders, such as CNS demyelinating disorders, using repair agents (eg, LINGO-1 antagonists). In certain embodiments, the methods and compositions described herein comprise a repair agent (eg, a LINGO-1 antagonist) as a single agent therapy or in combination with an immunomodulatory agent. In certain embodiments, to promote one or more of myelination, remyelination, differentiated oligodendrocyte count, or neuroaxonal protection in a subject, eg, a human (eg, a human MS patient) The repair agent is administered at selected time intervals. [Selection] Figure 18B |