| abstract |
The present invention provides an inhibitor of tropomyosin-related kinase A (TrkA), formula I: [Chemical 1] Wherein Ra, Rb, Rc, Rd, R1, R2, L, and Het-Ar are as defined herein, or a stereoisomer, tautomer thereof, or It is intended for pharmaceutically acceptable salts, metabolites, isotopes, solvates, or prodrugs. These compounds can be used for pain, inflammation or inflammatory diseases, cancer, atherosclerosis, restenosis, thrombosis, neurodegenerative diseases, erectile dysfunction (ED), skin diseases, autoimmune diseases such as multiple sclerosis, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, infection, diseases associated with imbalance of bone remodeling, endometriosis, pelvic pain syndrome, and abnormal tissue remodeling and fibrosis Diseases resulting from the disorder; or diseases or disorders associated with abnormal activity of the nerve growth factor (NGF) receptor TrkA, such as a disease, disorder, injury or dysfunction associated with dysmyelination or demyelination It can be used for prophylactic and / or therapeutic treatments. |