abstract |
The present invention relates to bifunctional compounds that are useful for degrading (and inhibiting) androgen receptors. In particular, the present invention includes at one end a VHL ligand that binds to a ubiquitin ligase such that the androgen receptor is placed in close proximity to the ubiquitin ligase to effect degradation (and inhibition) of the androgen receptor, The present invention relates to a compound comprising a moiety that binds to the body at the other end. The present invention exhibits a wide range of pharmacological activities associated with the compounds of the present invention, consistent with androgen receptor degradation / inhibition. |