| abstract |
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treating, preventing or reducing various medical disorders, such as migraine, using the compounds and pharmaceutical compositions disclosed herein. It is. In still other embodiments, provided herein is a compound and pharmaceutical composition disclosed herein, for example, 5-HT 1A receptor without activating 5-HT 2B receptor. Body, 5-HT 1Bm receptor and 5-HT 1D receptor. In yet other embodiments, provided herein antagonize 5-HT 2B , adrenergic α 2A and / or α 2B receptors using the compounds and pharmaceutical compositions disclosed herein. Is the method. In still other embodiments, provided herein are methods for antagonizing D2 and D3 receptors using the compounds and pharmaceutical compositions disclosed herein. |