| abstract |
The present disclosure relates to vaccines, antibodies targeting SSEA3 / SSEA4 / GloboH related epitopes (natural and modified) that induce the production of antibodies and / or binding fragments useful for modulating globo-based glycosphingolipid synthesis, and Intended for immunogenic conjugate compositions. The present disclosure relates to methods and compositions capable of modulating globo-type glycosphingoglycolipid synthesis. In particular, the present disclosure is directed to glycoenzyme inhibitor compounds and compositions and methods of their use that can modulate the synthesis of the globo glycosphingolipids SSEA3 / SSEA4 / GloboH in the biosynthetic pathway. In particular, glycoenzyme inhibitors target alpha-4GalT, beta-4GalNAcT-I or beta-3GalT-V enzymes in the globo-based synthesis pathway. |