| abstract |
The present invention provides amides that inhibit cellular necrosis and / or human receptor interacting protein 1 kinase (RIP1), which amides include their corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and Includes stereoisomers. The compound is used in pharmaceutical compositions and methods of manufacture and use, treating a human in need thereof with an effective amount of the compound or composition, and resulting in the health or condition of the human. Including detecting improvements. |