| abstract |
The present invention relates to a biaryl derivative represented by the formula (1), a method for producing the same, a pharmaceutical composition containing the biaryl derivative, and a use thereof, and the biaryl derivative represented by the formula (1) according to the present invention is a GPR120 agonist in the gastrointestinal tract. Promotes GLP-1 production, improves insulin resistance in liver and muscle by anti-inflammatory action on macrophages and pancreatic cells, etc. Diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis It can be usefully used for the prevention and treatment of metabolic diseases such as osteoporosis and inflammation. |