| abstract |
Compounds that are sodium channel inhibitors and the provision of these compounds in the treatment of various disease states such as cardiovascular disease and diabetes. A compound of formula I. (—YZ— is —C (═NR 4 ) —NR 2 — or —C (NR 5 R 6 ) ═N—; R 1 is aryl, cycloalkyl, cycloalkenyl, heterocyclyl or heteroaryl; R 2 is H, C 1-6 alkyl, ketone, ester, amide, sulfonamido, cycloalkyl, aryl, heteroaryl or heterocyclyl; each R 3 is independently C 1-6 alkyl, cycloalkyl, aryl, heteroaryl or Heterocyclyl; R 4 to R 6 are alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl and the like; n represents 0 to 4). [Selection figure] None |