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publicationDate 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2018189607-A
titleOfInvention Liquid chromatograph mass spectrometer and liquid chromatograph mass spectrometer
abstract When a sample containing various compounds is subjected to LC / MS analysis, ionization efficiency for each compound is improved to improve detection sensitivity. In a post-column addition section 16, additive liquid feed pumps 164A and 164B suck and feed different types of additives A and B from containers 163A and 163B, respectively, and eluate through three-way joints 162 and 161. Into. The combination of the additives is preferably a combination of DMSO capable of obtaining an aggregation effect of charge state and 2-propanol having an effect of promoting the refinement and vaporization of droplets. By mixing these two types of additives into the eluate while mixing them at an appropriate flow rate ratio according to a predetermined flow rate program, the ionization efficiency when ionizing the eluate from the ESI spray 21 while being charged and sprayed is varied. A near-optimal condition can be achieved for the compound. Thereby, the detection sensitivity is also improved as compared with the conventional case. [Selection] Figure 1
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