| abstract |
The present invention relates to methods, assays, and compositions relating to allowing cells to enter a more pluripotent state without introducing foreign genetic material. A method for producing a cell mass containing cells that express Oct4, the method comprising subjecting the cells to low pH stress, wherein the low pH is a pH of 5.4 to 5.8. And the adjustment of pH is performed using ATP. A method wherein a cell mass is generated without the introduction of foreign genes, transcripts, proteins, nuclear components or cytoplasm, or without cell fusion. [Selection] Figure 5 |