| abstract |
Disclosed is a compound that modulates the function of a NOD-like receptor family, for example, PYRIN inflammasome / NOD2 nodosome, and is effective for the treatment and / or prevention of related diseases. SOLUTION: PYRIN and ASC constituting a PYRIN inflammasome are synthesized by wheat cell-free protein synthesis technology, combined with an amplified luminogenic proximity assay, and an in vitro cell-free PYRIN inflammasome reconstitution system is constructed. Nod2 and RIPK2 composing NOD2 nodosome were synthesized by wheat cell-free protein synthesis technology, combined with amplified luminous proximity assay to construct in vitro in vitro cell-free NOD2 nodosome reconstitution system and PYRIN inflammasome The compound to modulate. [Selection figure] None |