| abstract |
PROBLEM TO BE SOLVED: To provide a compound that regulates the function of inflammasome and is useful for treatment of diseases and conditions related to inflammasome. An NLRP3 classified as NOD-like receptors (NLRs), a signal transduction molecule apoptosis-like protein containing a CARD (ASC) is synthesized by wheat cell-free protein synthesis technology, and the amplified amount is amplified. In combination, an in vitro cell-free NLRP3 inflammasome reconstitution system was constructed. A compound that modulates the function of the NLRP3 inflammasome found by the system. [Selection figure] None |