| abstract |
Provided are designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16. A novel neo-epitope that contains fragments of the E6 and E7 proteins that are rearranged despite simultaneously containing essentially all possible T cell epitopes of HPV16 oncoproteins E6 and E7 Is a polypeptide having an undetectable transformation activity that is significantly reduced compared to wild-type E6 and E7. A nucleic acid molecule encoding the polypeptide. The encoded polypeptide is at least one epitope of a human papillomavirus (HPV) E2 protein, eg, HPV16 E2 protein. [Selection figure] None |