| abstract |
Disclosed is a nanoparticle suitable for use in a vaccine. The nanoparticles present a pathogen-derived antigen that surrounds and associates with the surfactant core, resulting in enhanced stability and good immunogenicity. Also disclosed are dosages, formulations and methods for preparing vaccines and nanoparticles. In one aspect, the present invention provides (i) a nanoparticle comprising a nonionic surfactant core and a viral glycoprotein, wherein the viral glycoprotein is associated with the core, and the surfactant is about A vaccine composition comprising nanoparticles present at 0.03% to about 0.05%; and (ii) a pharmaceutically acceptable buffer, wherein the nonionic surfactant is PS20, Nanoparticles selected from the group consisting of PS40, PS60, PS65 and PS80 are provided. [Selection figure] None |