| abstract |
[Problem] To provide a medicament useful as an antitumor agent, which exhibits an excellent inhibitory effect on cancer cell sphere formation and can be administered orally. A pharmaceutical comprising a 1,4-disubstituted imidazole derivative represented by the formula (1 '). [Ring Q 1 is a C 6-10 aryl group, etc .; R 1 and R 2 are H, etc .; W 1 is a C 1-4 alkylene group; W 2 is —NR 3a C (O) —, etc .; R 3a is H or C 1-6 alkyl group; ring Q 2 is a 5- to 10-membered heteroaryl group; W 3 is a C 1-4 alkylene group, etc .; n is an integer of 1 to 5; R 4 is independently H, C 1-6 alkyl group and the like; R 5 is a hydroxy group and the like] [Selection figure] None |