| abstract |
Human antibodies and their diagnostic and therapeutic uses for the treatment of neurological diseases United States Patent Application 20070227735 Kind Code: A1 It is possible to bind to and recognize neurons in the CNS and elicit responses in neurons of the CNS. Specific binding members, particularly human antibodies, particularly recombinant antibodies, and fragments thereof are provided. These antibodies are useful for neuroprotection and for diagnosis and treatment of conditions associated with nerve injury, nerve injury or neurodegeneration and neurodegenerative diseases. The antibodies, their variable regions, or CDR domain sequences, and fragments thereof of the present invention may also be used in therapy with chemotherapeutic agents, immunomodulators, or neuroactive agents and / or other antibodies, or fragments thereof. It can also be used in combination. The antibodies are exemplified by antibodies IgM12 and IgM42, the sequences of which are provided herein. [Selection figure] None |