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filingDate 2016-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2018095561-A
titleOfInvention Method for producing diphenylazetidine derivative
abstract To provide a highly efficient industrial production method of a diphenylazetidine derivative which is a raw material for producing a β-lactam derivative useful for the treatment and prevention of hypercholesterolemia such as arteriosclerosis. The general formula (I) [wherein R is a branched lower alkyl group, an allyl group, a lower alkyl group containing a lower alkoxy group, a lower alkyl group containing a lower thioalkyl group, a tetrahydropyranyl group, A triphenylmethyl group, a silyl group having a substituent, a phenyl group which may have a substituent, and a benzyl group which may have a substituent are shown. And a compound represented by the general formula (II) [wherein M represents MgCl, MgBr, MgI, Li. The compound represented by the general formula (III) is obtained by reacting the compound represented by formula (II) in a toluene solvent: wherein R is the same as in the general formula (I). ] The manufacturing method of the compound represented by this. [Selection figure] None
priorityDate 2016-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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