| abstract |
The present invention provides an FK506 derivative having no immunosuppressive activity and maintaining nerve regeneration activity, a method for producing the same, and a pharmaceutical composition for preventing or treating a nervous system disease including the same. 31-O-demethyl-FK506, 9-deoxo-31-O-demethyl FK506, or any one FK506 derivative selected from the group consisting of 9-deoxo-prolyl-FK506 represented by the following formula 2 A pharmaceutical composition for preventing or treating a nervous system disease. [Selection] Figure 1 |