abstract |
The present invention provides a new single chemical conjugate capable of effectively performing delivery efficiency, cellular uptake and / or endosome escape. 1) oligonucleotide; 2) one or more tetraGalNAc ligands of formula (I); optionally 3) one or more linkers; 4) one or more having a specific sequence And optionally 5) a modular composition comprising one or more targeting ligands, solubilizers, pharmacokinetic agents, lipids and / or masking agents. [Selection figure] None |