| abstract |
An antibody Fc region dimer that binds to a molecule that does not bind to a natural antibody Fc region and FcγR, but does not bind to each other simultaneously, a polypeptide that includes the Fc region dimer, and the polypeptide Pharmaceutical compositions and methods for their production are provided. An antibody Fc region dimer and a polypeptide containing the Fc region dimer, which have binding activity to an antigen and FcγR, respectively, but do not bind to the antigen and FcγR simultaneously, and an antigen and FcγR The present invention provides a method for producing a multispecific binding polypeptide capable of avoiding side effects that may occur when two are bound simultaneously, and a polypeptide suitable as a pharmaceutical. [Selection] Figure 4 |