| abstract |
The present invention provides a method for identifying a genetic variation associated with the onset of a target disease state (eg, Alzheimer's disease). A method comprising: determining a nucleotide sequence possessed by a plurality of individual human subjects at a target locus from a biological sample containing DNA, wherein the subject (i) Genetic variation at a genetic locus is observed in a plurality of human subjects, including determining, including both a subject afflicted with, and (ii) a subject not afflicted with the subject condition A method comprising composite sequence alignment analysis, wherein the sequence is identified from a nucleotide sequence. And a kit for determining whether the subject has an increased risk of developing late-onset Alzheimer's disease. [Selection] Figure 1 |