abstract |
PROBLEM TO BE SOLVED: To provide a new kinase which is a downstream protein kinase in a neuregulin signaling pathway. Nucleic acid encoding an isolated neukinase having a specific sequence, neukinase polypeptide, an oligonucleotide that hybridizes to the neukinase nucleic acid, an expression vector comprising a sequence encoding neukinase, and neukinase Isolated host cells, antibodies, transgenic non-human animals, compositions, and kits for kinases are included. In other embodiments, a method of identifying a predisposition to cardiac dysfunction, a method of detecting the presence of neukinase, a neukinase nucleic acid, a method of screening for agents that affect neukinase activity, and a method of modulating neukinase activity In addition. [Selection figure] None |