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filingDate 2016-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a1d170ca816430d67fa31ca84a21911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fadc33ead3c849ce68c4ae60ccc113a
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publicationDate 2018-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2018065752-A
titleOfInvention Silodosin-containing pharmaceutical composition and method for producing the same
abstract A silodosin-containing pharmaceutical composition for oral administration having higher storage stability under the action of light and temperature, and a method for producing the same. The pharmaceutical composition comprises silodosin or a pharmaceutically acceptable salt thereof and a low molecular weight basic additive. A method for producing a pharmaceutical composition comprises: 1a) a step of mixing silodosin or a pharmaceutically acceptable salt thereof and an excipient in a fluidized bed granulation dryer; 2a) a binder and a low molecular weight basic additive; And a step of preparing an aqueous solution by dissolving the solution in water and 3a) spraying and granulating the aqueous solution obtained in step 2a) on the mixture obtained in step 1a). 1b) mixing silodosin or a pharmaceutically acceptable salt thereof, an excipient, and a low molecular weight basic additive in a fluidized bed granulation dryer; 2b) dissolving the binder in water. It is preferable to include a step of preparing an aqueous solution and a step of 3b) spraying and granulating the aqueous solution obtained in step 2b) on the mixture obtained in step 1b). [Selection figure] None
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