| abstract |
Provided is a device having immobilized biological entities and a surface coating comprising such components. A device having a surface comprising a laminate coating, wherein the outer coating layer has (i) a core portion having a molecular weight of 14 to 1,000 Da, and (ii) a total molecular weight of 1,500 to 1,000. (Iii) the ratio of the total molecular weight to the molecular weight of the core portion is at least 80: 1 and (iv) having a functional end group, wherein the functional end group One or more include a plurality of cationic hyperbranched polymer molecules characterized by having an anticoagulant (eg, heparin) covalently bound thereto, wherein the laminate coating comprises a cationic polymer and an anionic polymer coating Contains one or more bilayers. [Selection figure] None |