| abstract |
PROBLEM TO BE SOLVED: To provide a new compound that inhibits breton agammaglobulinemia tyrosine kinase (Btk or BTK) and a therapeutic method using such a compound. A compound of formula (I) or a stereoisomer, pharmaceutically acceptable salt or pharmaceutically acceptable prodrug thereof. Wherein each R1, R2, R3 and R4 <is independently N or CR5, wherein each R5 is independently H, optionally substituted alkyl, etc. Is H, optionally substituted alkyl, etc., X is optionally substituted heterocyclyl, etc., L is optionally substituted alkylene, etc., each Z3a, Z3b and Z4 is , Independently, H, optionally substituted alkyl, and the like, and Y is optionally substituted bicyclic heterocyclyl. ] [Selection figure] None |