| abstract |
The present invention provides a silyl monomer capable of forming a biologically useful multimer when contacted with 1, 2, 3 or more other monomers in an aqueous medium. The association of monomers forming multimers is facilitated by the proximity of the monomers to their target biomolecules. Such a monomer can bind to another monomer in an aqueous medium (eg, in vivo) to form a multimer (eg, a dimer), which includes a ligand moiety, A linker element and a connector element that connects the ligand moiety and the linker element are included. In aqueous medium, the monomers can be linked via each linker element, thereby modulating one or more biomolecules substantially simultaneously (eg, on one protein or on a different protein). Can modulate two or more binding domains above). [Selection figure] None |