abstract |
An anti-HtrA1 antibody and a method of using the same are provided. An isolated anti-HtrA1 antibody that binds to HtrA1 (serine protease HtrA1), wherein the antibody binds to an epitope comprising Ntr, K248, or both of HtrA1, and (ii) an IC50 An antibody that inhibits HtrA1 at ≦ 30 nM. A production method for recovering an anti-HtrA1 antibody from a host cell containing a nucleic acid encoding the anti-HtrA1 antibody. Further provided is a method for use in the treatment of age-related macular degeneration, geographic atrophy, diabetic retinopathy, retinopathy of prematurity, or polypoidal choroidal vasculopathy. [Selection] Figure 14 |