| abstract |
PROBLEM TO BE SOLVED: To provide a novel circadian rhythm improving agent. The technical features of the present invention for solving the above-described problems are as follows. 1. A circadian rhythm improving agent containing a passiflora extract (excluding those containing harmin). 2. 1. The circadian rhythm improving agent has an action of regulating the amplitude and / or cycle length of an expression rhythm of a clock gene. The circadian rhythm improving agent described in 1. 3. 2. The clock gene described above, wherein the clock gene is a Per2 gene and / or a Cry2 gene. The circadian rhythm improving agent described in 1. 4). The above-mentioned Passiflora extract contains at least one selected from isovitexin, isoscaftside, homoorientin, scaftside, isovitexin-2 ″ -O-glucoside and derivatives thereof. ~ 3. The circadian rhythm improving agent as described in any one of these. [Selection figure] None |