| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-905
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate |
2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afc5ab89ae53f3905b9f5f146039386a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d63e6b755d5b373185e2d97c20942ee2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2f05b6246b6d896eb32dfbdfaaebe4f |
| publicationDate |
2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2018039808-A |
| titleOfInvention |
Rationally designed meganuclease with altered sequence specificity and DNA-binding affinity |
| abstract |
[PROBLEMS] To provide a method for treating human diseases by gene therapy in eukaryotic cells using a recombinant meganuclease having altered specificity for at least one recognition sequence half site compared to wild-type I-CREI meganuclease. . An I-CREI comprising a polypeptide having at least 85% sequence similarity to a residue 2-153 of an I-CREI meganuclease of a specific amino acid sequence and selected from five specific SEQ ID NOs A method of using a recombinant meganuclease comprising a specific at least one modification that is specific for a half site within the meganuclease recognition sequence and a recognition sequence half site that differs by at least one base pair and is not an exogenous modification. [Selection figure] None |
| priorityDate |
2005-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |