| abstract |
Compositions and methods related to improving the pharmacological properties of biologically active compounds that target the nervous system. The present invention relates to an isolated polypeptide having an amino acid sequence at least about 90% identical to a galanin analog or the like having a specific amino acid sequence having anticonvulsant activity, or one or more conservative amino acid substitutions. In addition, compositions with high blood-brain barrier permeability are disclosed, including peptides that have high lipophilic properties and high basicity when compared to the unmodified form of the peptide. [Selection] Figure 1 |