| abstract |
The present invention provides a coloring inhibitor and a coloring suppression method capable of suppressing coloration with time of an external pharmaceutical composition containing luliconazole and / or a pharmaceutically acceptable salt thereof. Furthermore, to provide a histamine release inhibitor containing luliconazole and / or a pharmaceutically acceptable salt thereof, and an external pharmaceutical composition for antipruritics comprising the same. (A) Luliconazole and / or a pharmaceutically acceptable salt thereof, and (B) an antihistamine, a local anesthetic, a cooling agent, an anti-inflammatory, a vitamin, a pH adjuster, and a fungicide. An external pharmaceutical composition containing one or more selected from the group is prepared. The resulting composition has reduced coloration over time due to luliconazole and / or pharmaceutically acceptable salts thereof. Furthermore, it has an antifungal action and a histamine release inhibitory action. [Selection figure] None |