| abstract |
Provided is a potent antagonist of CCR (9) receptor related to human inflammatory disease (IBD) including celiac disease, food allergy, Crohn's disease, ulcerative colitis and the like. A pyrazol-1-ylbenzenesulfonamide compound represented by formula (I). [R1 is substituted or unsubstituted C2-8 alkyl, etc .; R2 is H, F, Cl etc .; R3 is H, alkyl etc .; R4 is H or F; R5 is H, F, Cl or CH3; R6 is H, halo , CN, NH2, alkyl, etc .; L is a bond, CH2 or CH (CH3); A1-8 is N, N—O or CR8, one or two are N or N—OR8 is H, halo, etc.] Selection diagram] None |