| abstract |
The present invention provides a pharmaceutical composition for the treatment of tumors. Bispecific antibody or antigen binding thereof comprising a first arm that binds to PD-1 or PD-L1 and antagonizes PD-1 activity, and a second arm that binds to GITR and stimulates GITR activity A pharmaceutical composition for the treatment of tumors comprising a sex fragment. A pharmaceutical composition wherein the first arm is selected from antigen binding fragments from BMS-936558, MK-3475 and MPDL3280A. The second arm is a) a heavy chain comprising a variable heavy chain CDR-H1, CDR-H2 and CDR-H3 comprising a specific amino acid sequence, and b) a special amino acid sequence (amino acid 31 is N, amino acid 57 Is a variable light chain CDR-L1, CDR-L2 and CDR-L3. [Selection] Figure 1A |