| abstract |
Compound, for example a compound of formula I Wherein R, R 0 , R 1 to R 8 , n, X, Y, Y ′, and E are as described herein, pharmaceutical compositions containing such compounds Products, as well as methods of treating or preventing diseases or conditions mediated by the ras gene, eg, cancer. The present invention is a method of therapeutically treating a cancer patient, for example, where the cancer has been determined to contain a Ras activating mutation of the ras gene, wherein said patient is selected for more than one of Ras inhibitory effective amounts. There is provided a method comprising administering at least one Ras inhibitory compound of formula II having a sex index, a pharmaceutically acceptable salt or prodrug thereof. [Selection] Figure 10A |