abstract |
Methods are provided for multiple administrations of cells for adoptive cell therapy, and for administration of cells to a subject who has received prior administration, as well as compositions and products for use in the present methods. The cells generally express a recombinant molecule, such as a recombinant receptor, such as a chimeric antigen receptor (CAR) and / or other transgenic receptors. The method involves the expression of a cell that expresses a first or previous receptor, and generally a cell that does not express a first receptor and expresses a second or subsequent receptor different from the first. Administering and / or administering a cell expressing the second receptor to a subject who has received the first administration. The method improves the efficacy in the context of an immune response in a subject to the first or prior receptor and / or in the context of antigen loss, down-regulation, or modification after the first or prior administration. Various advantages can be provided. |