http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017536132-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-608 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-998 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2015-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017536132-A |
| titleOfInvention | Method of reducing the carcinogenicity of induced pluripotent stem cells derived from old age donors |
| abstract | (A) Inducible pluripotent stem cells (A-iPSCs) from old age donors compared with those from young donors (Y-iPSCs) have increased genomic instability, abnormal apoptosis, abnormal glucose metabolism, and blunted And (b) association with A-iPSCs, and inhibition of excess glutathione-mediated H 2 O 2 excision activity, which was found to inhibit DNA damage response and apoptosis as a result, The discovery is disclosed that substantially rescues these abnormalities and reduces the carcinogenic potential of A-iPSCs. Recruitment of the pluripotency factor ZSCAN10 (low activity at A-iPSCs and shown to act upstream of glutathione-related), eg by expression as an adjunct to the four Yamanaka iPSC reprogramming factors, In A-iPSCs, enhanced GLUT3 and normalization of glutathione / H 2 O 2 homeostasis results in significant restoration of genomic stability, DNA damage response and apoptosis; GLUT3 (acting upstream of glutathione, in A-iPSCs (Less active pluripotent stem cell-specific glucose transporters) have similar effects, and in particular the inhibition of glutathione / H 2 O 2 by delivery of ZSCAN10 and / or GLUT3 and / or exosomal subunits is clinically Useful and improved properties and Indicates that results in A-iPSC of reduced carcinogenic. [Selected figure] Figure 1G |
| priorityDate | 2014-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 521.